Serum Insufficiency Induces RANKL-Independent Osteoclast Formation during Developing Ischemic ONFH

MicroRNA-26a Regulates RANKL-Induced Osteoclast Formation

Osteoclasts are unique cells responsible for the resorption of bone matrix. MicroRNAs (miRNAs) are involved in the regulation of a wide range of physiological processes. Here, we examined the role of miR-26a in RANKL-induced osteoclastogenesis. The expression of miR-26a was up-regulated by RANKL at the late stage of osteoclastogenesis. Ectopic expression of an miR-26a mimic in osteoclast precur...

RANKL induces NFATc1 acetylation and stability via histone acetyltransferases during osteoclast differentiation.

NFATc1 (nuclear factor of activated T-cells c1), a key transcription factor, plays a role in regulating expression of osteoclast-specific downstream target genes such as TRAP (tartrate-resistant acid phosphatase) and OSCAR (osteoclast-associated receptor). It has been shown that RANKL [receptor activator of NF-κB (nuclear factor κB) ligand] induces NFATc1 expression during osteoclastogenesis at...

Osteoclast Formation and Activity FOXO1 Mediates RANKL-Induced

The involvement of M-CSF and RANKL in mitochondrial biogenesis during osteoclast formation and macrophage differentiation

Bone resorption is characterized by a high release of protons, a process associated with a serious energy demand and thus many mitochondria. Although the high number of these organelles is a well-known characteristic of osteoclasts, surprisingly little is known about their biogenesis during osteoclast differentiation. In this study we investigated the role of macrophage colony-stimulating facto...

Incorporation of RANKL promotes osteoclast formation and osteoclast activity on β-TCP ceramics.

β-Tricalcium phosphate (β-TCP) ceramics are approved for the repair of osseous defects. In large defects, however, the substitution of the material by authentic bone is inadequate to provide sufficient long-term mechanical stability. We aimed to develop composites of β-TCP ceramics and receptor activator of nuclear factor κ-B ligand (RANKL) to enhance the formation of osteoclasts and promote ce...